Southmead Hospital is well served by buses. First Bus numbers 17, 18, 82 & Wessex Services numbers 501, 502, 505, 506 stop outside the Brunel Building itself. First Bus numbers 76 and 24 stop outside the entrance on Monks Park Avenue. Number 76 also stops outside the entrance on Southmead Road.

The hospital grounds have several bike racks, a large bike rack is at the rear of the multi-storey car park near the Beaufort Building.

To reach The Macmillan Wellbeing Centre from the Brunel Building follow Tyndalls Way, then turn left onto Beaufort Way, following signs to the Centre after Elgar House on the left, accompanied by red dots on the concrete surface.

[A] Brunel Building - This is the key development within the project to merge Southmead and Frenchay hospitals on one single site. The building opened spring 2014. According to North Bristol NHS Trust's website 'the Brunel building sees the end of traditional wards. The 800-bed building has single rooms with en-suite facilities and single-sex four-bed wards offering more single rooms than any other NHS hospital in the country, greatly improving privacy and dignity and helping to control the spread of infections. The design and layout of the Brunel building means that patients and visitors will find it very easy to navigate. There is one main entrance and relevant departments are located next to each other, cutting down on travel times around the site. The Brunel building is one of the most environmentally-friendly buildings in the country and is bright and airy with outside views.'

[B] St. Gregory the Great Church

[C] Poet's Park - young person's play area.